RNAgent’s Drug Interaction Database indexes and lists prescription drugs and their interactions with herbal supplements. Search by letter or keyword to find a prescription drug and its interactions with herbal and natural ingredients.
Cimetidine
- Cimetidine may increase the risk for deficiencies in calcium, magnesium, iron, zinc, and vitamin D. Discuss a nutritional supplement plan with your physician or pharmacist.
- Aymard JP, Aymard B, Netter P, et al. Haematological adverse effects of histamine H2-receptor antagonists. Med Toxicol Adverse Drug Exp 1988;3:430-48.
- Hakanson R, Persson P, Axelson J: Elevated serum gastrin after food intake or acid blockade evokes hypocalcemia, Regul Pept, 1990, 28(2):131-6.
- Ghishan FK, Walker F, Meneely R, et al: Intestinal calcium transport - effect of cimetidine, J Nutr, 1981, 111(12): 2157-61.
- Odes HS, Fraser GM, Krugliak P, et al: Effect of cimetidine on hepatic vitamin D metabolism in humans, 1990, 46(2):61-4.
- Skikne BS, Lynch SR, Cook JD: Role of gastric acid in food iron absorption, Gastroenterology, 1981, 81(6):1068-71.
- Sturniolo GC, Montino MC, Rossetto L, et al: Inhibition of gastric acid secretion reduces zinc absorption in man, J Am Coll Nutr, 1991, 10(4):372-5.
- Noted nutritional deficiencies exist between Cimetidine, and the nutrients folic acid and vitamin B-12. Supplementation is recommended. For optimal benefit, a B-Complex supplement is recommended.
- Aymard JP, Aymard B, Netter P, et al. Haematological adverse effects of histamine H2-receptor antagonists. Med Toxicol Adverse Drug Exp 1988;3:430-48.
- Force RW, Nahata MC: Effect of histamine-H2-Receptor antagonists on vitamin B12 absorption, Ann Pharmacother, 1992, 26(10):1283-6.
- Russell RM, Golner BB, Krasinski SD, et al: Effect of antacid and H2 receptor antagonists on the intestinal absorption of folic acid, J Lab Clin Med, 1988, 112(4):458-63.
- Avoid alcohol and tobacco, both of which affect Cimetidine.
- Pronsky, ZM: Food-Medication Interactions, 11th edition, 1999
- Lieber, CS: Mechanisms of ethanol-drug-nutrition interactions. J Toxicol Clin Toxicol 1994;32(6):631-81.
- Schurer-Maly CC, Varga L, Koelze HR, Halter F. Smoking and pH response to H2-receptor antagonists. Scand J Gastroenterol 1989;24:1172-78.
- Limit caffeine intake. This includes coffee, tea, sodas, chocolate, and caffeine-containing nutritional supplements.
- Pronsky, ZM: Food-Medication Interactions, 11th edition, 1999
- Facts and Comparisons, Clinisphere 2.0, Wolters Kluwer Company, 2000
- Avoid black tea, cocoa, coffee, cola nut, guarana, green tea and mate because the caffeine can interfere with H2 antagonists.
- Brinker, F Herb Contraindications and Drug Interactions, Eclectic Medical Publications, 1998.
- Licorice may theoretically provide an added protective effect with H2 antagonists.
- Brinker, F Herb Contraindications and Drug Interactions, Eclectic Medical Publications, 1998