RNAgent’s Drug Interaction Database indexes and lists prescription drugs and their interactions with herbal supplements. Search by letter or keyword to find a prescription drug and its interactions with herbal and natural ingredients.
Captopril
- Avoid arginine with ACE inhibitors because it could cause hyperkalemia.
- McKevoy GK, ed. AHFS Drug Information. Bethesda, MD: American Society of Health-System Pharmacists, 1998
- Bushinsky DA, Gennari FJ. Life-threatening hyperkalemia induced by arginine. Ann Intern Med. 1978 Nov;89(5 Pt 1):632-4.
- Doman K, Perlmutter JA, Muhammedi M, Puschett JB. Life-threatening hyperkalemia associated with captopril administration. South Med J. 1993 Nov;86(11):1269-72.
- Avoid salt substitutes and be careful of using potassium and magnesium supplements, because ACEIs can raise potassium levels. Electrolytes should also be monitored regularly.
- Burnakis TG & Mioduch HJ: Combined therapy with captopril and potassium supplementation: a potential for hyperkalemia. Arch Intern Med 1984; 144:2371-2372
- Facts and Comparisons, Clinisphere 2.0, Wolters Kluwer Company, 2000
- Pronsky, Z Food Medication Interactions, 11th edition, 1999
- Monitor zinc levels, it is possible to deplete levels with ACEIs.
- Golik A, Zaidenstein R, Dishi V, et al: Effects of captopril and enalapril on zinc metabolism in hypertensive patients, J Am Coll Nutr, 1998, 17(1):75-8
- Monitor sugar levels, especially with diabetics because ACEIs can affect sugar levels.
- Pronsky, Z Food Medication Interactions, 11th edition, 1999.
- Rett K, Wicklmayr M & Dietze GJ: Hypoglycemia in hypertensive diabetic patients treated with sulfonylureas, biguanides, and captopril. N Engl J Med 1988; 319:1609.
- Avoid or limit caffeine and alcohol.
- Pronsky, Z Food Medication Interactions, 11th edition, 1999.
- Facts and Comparisons, Clinisphere 2.0, Wolters Kluwer Company, 2000
- These herbs may have cardiac properties which could intensify the effects of captopril : black hellebore, calamus, cereus, cola, coltsfoot, devil's claw, European mistletoe, fenugreek, fumitory, digitalis leaf, hedge mustard, figwort, lily of the valley roots, motherwort, pleurisy root, squill bulb leaf scales, white horehound, mate, scotch broom flower, shepherd's purse, and wild carrot
- Brinker, F Herb Contraindications and Drug Interactions, Eclectic Medical Publications, 1998.
- Newall CA, Anderson LA, Phillipson JD. Herbal Medicines: A Guide for Health-care Professionals. London: The Pharmaceutical Press, 1996.
- PDR for Herbal Medicines, 2nd edition, Medical Economics Company, 2000
- The Review of Natural Products, Clinisphere 2.0, Wolters Kluwer Company, 2000
- These herbs may have diuretic properties which could intensify the effects of captopril: Alfalfa, Angelica, Astragalus, Basil, Bean Pod, Buckthorn, Burdock, Butchers Broom, Buchu, Celery, Cleavers, Cornflower, Dandelion, Elecampane, Elder, Goat's Rue, Hempnettle, Horsetail, Indian-Hemp, Juniper, Marigold, Meadowsweet, Parsley, Rauwolfia, Sarsaparilla, Sweet clover, Turmeric, and Vervain.
- PDR for Herbal Medicines, 2nd edition, Medical Economics Company, 2000
- Newall CA, Anderson LA, Phillipson JD. Herbal Medicines: A Guide for Health-care Professionals. London: The Pharmaceutical Press, 1996.