Benazepril

• Avoid consuming excessive potassium in foods and supplements when taking this medication, including salt substitutes.
• Good CB, McDermott L, McCloskey B. Diet and serum potassium in patients on ACE inhibitors. JAMA 1995;274:538.
• Burnakis TG & Mioduch HJ: Combined therapy with captopril and potassium supplementation. A potential for hyperkalemia. Arch Intern Med 1984; 144:2371-2372.
• Alcohol intake should be limited.
• Pronsky, ZM: Food-Medication Interactions, 11th edition, 1999
• This medication may contribute to a deficiency in zinc. Supplementation may be considered.
• Golik A, Modai D, Averbukh Z, et al: Zinc metabolism in patients treated with captopril versus enalapril, Metabolism, 1990, 39(7): 665-7.
• Golik A, Zaidenstein R, Dishi V, et al: Effects of captopril and enalapril on zinc metabolism in hypertensive s, J Am Coll Nutr, 1998, 17(1):75-8.
• Avoid arginine in conjunction with these agents, because there is a potential for hyperkalemia to develop.
• McKevoy GK, ed. AHFS Drug Information. Bethesda, MD: American Society of Health-System Pharmacists, 1998.
• N-acetylcysteine may have additive blood pressure lowering effects with this medication.
• Ruiz FJ, Salom MG, Ingles AC, Quesada T, Vicente E, Carbonell LF.N-acetyl-L-cysteine potentiates depressor response to captopril and enalaprilat in SHRs. Am J Physiol. 1994 Sep;267(3 Pt 2):R767-72.
• Surez C, Del Arco C, Lahera V, Ruilope LM. N-Acetylcysteine potentiates the antihypertensive effect of angiotensin converting enzyme inhibitors [letter]. Am J Hypertens. 1995;8:859-861.
• Olive oil has been shown to reduce blood pressure, if used on a regular basis, antihypertensive drug dosage adjustment may need to be made.
• Ruiz-Gutierrez V, Muriana FJ, Guerrero A, Cert AM, Villar J. Plasma lipids, erythrocyte membrane lipids and blood pressure of hypertensive women after ingestion of dietary oleic acid from two different sources. J Hypertens 1996 Dec;14(12):1483-90
• Baroni SS, Amelio M, Sangiorgi Z, Gaddi A, Battino M. Solid monounsaturated diet lowers LDL unsaturation trait and oxidisability in hypercholesterolemic (type IIb) patients. Free Radic Res. 1999 Apr;30(4):275-85.
• Ferrara LA, Raimondi AS, d'Episcopo L, et al. Olive oil and reduced need for antihypertensive medications. Arch Intern Med 2000;160(6):837-842.
• CoQ10 may decrease blood pressure, therefore if combining this supplement with this medication, a dosage adjustment may need to be made.
• Langsjoen P, Langsjoen P, Willis R, Folkers K. Treatment of essential hypertension with coenzyme Q10. Mol Aspects Med. 1994;15 Suppl:S265-72.
• Some herbs possess cardiac properties that may interact with the action of this drug and may result in an excessive lowering of blood pressure or increased side effects. Such herbs include: black hellebore, calamus, cereus, cola, coltsfoot, devil's claw, European mistletoe, fenugreek, fumitory, digitalis leaf, hedge mustard, figwort, lily of the valley roots, motherwort, pleurisy root, squill bulb leaf scales, white horehound, mate, and shepherd's purse.
• PDR for Herbal Medicines, 2nd edition, Medical Economics Company, 2000
• Facts and Comparisons, The Review of Natural Products, Clinisphere 2.0, Wolters Kluwer Company, 2000
• Newall CA, Anderson LA, Phillipson JD. Herbal Medicines: A Guide for Health-care Professionals. London: The Pharmaceutical Press, 1996.
• Avoid natural licorice products, Ginseng, and Ephedra (Ma huang) which may contribute to high blood pressure
• PDR for Herbal Medicines, 2nd edition, Medical Economics Company, 2000
• Brinker, F Herb Contraindications and Drug Interactions, Eclectic Medical Publications, 1998
• Pronsky, ZM: Food-Medication Interactions, 11th edition, 1999