RNAgent’s Drug Interaction Database indexes and lists prescription drugs and their interactions with herbal supplements. Search by letter or keyword to find a prescription drug and its interactions with herbal and natural ingredients.

Ortho Tri-Cyclen	Prozac	Claritin
Zoloft	Viagra	Claritin-D
Premarin	Codeine	Paxil
Prempro	Lipitor	Zocor

Azathioprine

There are no known nutritional considerations, at this time.

Based on pharmacology: Laboratory studies have reported that constituents contained in shiitake mushroom may increase immune function which may alter the effects of Azathioprine and possibly the dose needed for treatment. Use with caution.

Suzuki H, et al. Immunopotentiating Substances in Lentinus edodes Mycelial Extract(LEM)-- Activation of Macrophage and Proliferation of Bone Marrow Cell. Nippon Shokakibyo Gakkai Zasshi. Jul1988;85(7): 1430.
Suzuki H, et al. Inhibition of the Infectivity and Cytopathic Effect of Human Immunodeficiency Virus by Water-soluble Lignin in an Extract of the Culture Medium of Lentinus edodes Mycelia (LEM). Biochem Biophys Res Commun. Apr1989;160(1):367-73.

Based on pharmacology: Laboratory studies have reported that constituents contained in picrorhiza root/rhizome may increase immune function which may alter the effects of Azathioprine and possibly the dose needed for treatment. Use with caution.

Atal CK, et al. Immunomodulating Agents of Plant Origin. I: Preliminary Screening. J Ethnopharmacol. Nov1986;18(2):133-41.
Sharma ML, et al. Immunostimulatory Activity of Picrorhiza kurroa Leaf Extract. J Ethnopharmacol. Feb1994;41(3):185-92.

Based on pharmacology: Laboratory studies have reported that constituents contained in larch arabinogalactan may increase immune function which may alter the effects of Azathioprine and possibly the dose needed for treatment. Use with caution.

Hauer J, et al. Mechanism of Stimulation of Human Natural Killer Cytotoxicity by Arabinogalactan from Larix occidentalis. Cancer Immunol Immunother. 1993;36(4):237-44.

Based on pharmacology: Human and laboratory studies have reported that constituents contained in echinacea products may increase immune function which may alter the effects of Azathioprine and possibly the dose needed for treatment. Use with caution.

Vomel VT. The Effect of a Nonspecific Immunostimulant on the Phagocytosis of Erythrocytes and Ink by the Reticulohistiocyte System in the Isolated, Perfused Liver of Rats of Various Ages. Arzneim Forsch/Drug Res. 1984;34:691-95.
See DM, et al. In Vitro Effects of Echinacea and Ginseng on Natural Killer and Antibody-dependent Cell Cytotoxicity in Healthy Subjects and Chronic Fatigue Syndrome or Acquired Immunodeficiency Syndrome Patients. Immunopharmacology. 1997;35(3):229-35.

Based on pharmacology: Studies have reported that cat's claw has immuno-stimulatory properties which may alter the effects of Azathioprine and possibly the dose needed for treatment. Use with caution.

Wagner H, et al. The Alkaloids of Uncaria tomentosa and Their Phagocytosis-stimulating Action. Planta Med. 1995;5:419-23.

Based on pharmacology: Laboratory studies have reported that constituents contained in calendula flowers may increase immune function which may alter the effects of Azathioprine and possibly the dose needed for treatment. Use with caution when taking this supplement internally.

Wagner H, et al. Immunostimulating action of polysaccharides (heteroglycans) from higher plants. Arzneimittelforschung. 1985;35(7):1069-75.

Based on pharmacology: Laboratory studies have reported that constituents contained in astragalus root may increase immune function which may alter the effects of Azathioprine and possibly the dose needed for treatment. Use with caution.

Zhao KS, et al. Enhancement of the Immune Response in Mice by Astragalus membranaceus Extracts. Immunopharmacology. 1990;20(3):225-33.
Chu DT, et al. Immune Restoration of Local Xenogeneic Graft-versus-host Reaction in Cancer Patients in In-vitro and Reversal of Cyclophosphamide-induced Immune Suppression in the Rat in Vivo by Fractionated Astragalus membranaceus. Chung Hsi I Chieh Ho Tsa Chih. Jun1989;9:351-54.

Based on pharmacology: Studies have reported that arabinoxylane may increase immune function and therefore may alter the effects of Azathioprine and possibly the dose needed for treatment. Use with caution.

Ghoneum M, et al. NK IMMUNOMODULATORY FUNCTION IN 27 CANCER PATIENTS BY MGN-3, A MODIFIED ARABINOXYLANE FROM RICE BRAN, 87th Annual Meeting of the American Association for Cancer Research. Washington DC. Apr1996.
Ghoneum M. ENHANCEMENT OF HUMAN NATURAL KILLER CELL ACTIVITY BY MODIFIED ARABINOXYLANE FROM RICE BRAN (MGN-3). INTERNATIONAL JOURNAL OF IMMUNOTHERAPY XIV(i). 1998;89-99.

Based on pharmacology: Studies have reported that constituents contained in St. John's wort flowers may alter the function of certain cytochrome P450 isoenzyme systems which may change the effects of Azathioprine and possibly the dose needed for treatment. A case report found that St. John's wort decreased the effects of this medication. Use with caution.

Ruschitzka F, et al. Acute Heart Transplant Rejection Due to St. John's Wort. Lancet. Feb2000;355(9203): 548-49.