Arthrotec

• Folate and vitamin C supplementation may be helpful with long term use of the medication.
• Baggott JE, Morgan SL, Ha T, et al. Inhibition of folate-dependent enzymes by non-steroidal anti-inflammatory drugs. Biochem J 282: 197-202, 1992.
• Lawrence VA, Loewenstein JE, and Eichner ER. Aspirin and folate binding: in vivo and in vitro studies of serum binding and urinary excretion of endogenous folate. J Lab Clin Med 103: 944-948, 1984.
• Molloy TP and Wilson CW. Protein-binding of ascorbic acid. Interaction with acetylsalicylic acid. Int J Vitam Nutr Res 50: 387-392, 1980.
• Das N and Nebioglu S. Vitamin C-aspirin interactions in laboratory animals. J Clin Pharm Ther 17: 343-346, 1992.
• Vitamin E intake with NSAIDs may increase risk of bleeding.
• Liede KE, Haukka JK, Saxen LM, et al. Increased tendency toward gingival bleeding caused by joint effect of alpha-tocopherol supplementation and acetylsalicylic acid. Ann Med 30: 542-546, 1998.
• Steiner M. Vitamin E, a modifier of platelet function: rationale and use in cardiovascular and cerebrovascular disease. Nutr Rev. 1999 Oct;57(10):306-9.
• Take with food or milk to decrease stomach upset
• Pronsky, Z Food Medication Interactions, 11th edition, 1999.
• Facts and Comparisons, Clinisphere 2.0, Wolters Kluwer Company, 2000
• Avoid alcohol.
• Pronsky, Z Food Medication Interactions, 11th edition, 1999.
• Facts and Comparisons, Clinisphere 2.0, Wolters Kluwer Company, 2000
• Chondroitin sulfate has some anti-platelet properties; consult a pharmacist prior to using NSAID's and chondroitin together due to the increased potential for bleeding.
• McKevoy GK, ed. AHFS Drug Information. Bethesda, MD: American Society of Health-System Pharmacists, 2000.
• Griffith, Winter H MD Vitamins, herbs, minerals and supplements- the complete guide. Revised edition. Fisher books, 1998.
• Ulcers induced by NSAIDs may be minimized by Licorice.
• Rees WDW, Rhodes J, Wright JE, et al. Effect of deglycyrrhizinated liquorice on gastric mucosal damage by aspirin. Scand J Gastroenterol 14: 605-607, 1979.
• Brinker, F Herb Contraindications and Drug Interactions, Eclectic Medical Publications, 1998
• Morgan AG, McAdam WAF, Pascoo C, Darnborough A. Comparison between cimetidine and Caved-S in the treatment of gastric ulceration and subsequent maintenance therapy. Gut 1982;23: 545-51.
• Due to its blood-thinning properties, taking Ginkgo with NSAIDs may not be advisable.
• Rosenblatt M and Mindel J. Spontaneous hyphema associated with ingestion of Ginkgo biloba extract. N Engl J Med 336(15): 1108, 1997.
• Anti-inflammatory properties of diclofenac may be increased by Stinging Nettle.
• Chrubasik S, Enderlein W, Bauer R, Grabner W. "Evidence for antirheumatic effectiveness of Herba Urticae dioicae in acute arthritis: A pilot study," Phytomedicine, 4(2): 105-108, 1997.
• Brinker, F Herb Contraindications and Drug Interactions, Eclectic Medical Publications, 1998
• Avoid feverfew with NSAID's, the herbs' effect may theoretically be reduced.
• The Review of Natural Products by Facts and Comparisons. St. Louis, MO: Wolters Kluwer Co., 2000.
• Miller LG. Herbal medicinals: selected clinical considerations focusing on known or potential drug-herb interactions. Arch Int Med 1998;158(20):2200-11.