Amaryl

• There is some evidence that metformin, a sulfonylurea class drug may cause vitamin B12 deficiency. Amaryl may also have similar effects, monitor blood levels periodically with long term use of this medication.
• Adams JF, Clark JS, Ireland JT, et al: Malabsorption of vitamin B12 and intrinsic factor secretion during biguanide therapy, Diabetologia, 1983, 24(1):16-8.
• Berger W, Incidence of severe side effects during therapy with sulfonylureas and biguanides, Horm Metab Res Suppl, 1985, 15:111-5.
• Rieder HP, Berger W, and Fridrich R: Vitamin status in diabetic neuropathy, Z Ernahrungswiss, 1980, 19 (1):1-13.
• Carpentier JL, Bury J, Luyckx A, et al: Vitamin B12 and folic acid serum levels in diabetics under various therapeutic regimens, Diabete Metab, 1976, 2(4):187-90.
• High doses of niacin may increase blood glucose levels, and excessive use of this nutrient should be avoided in diabetes.
• McKevoy GK, ed. AHFS Drug Information. Bethesda, MD: American Society of Health-System Pharmacists, 1998.
• Schwartz ML. Severe reversible hyperglycemia as a consequence of niacin therapy. Arch Intern Med. 1993 Sep 13;153(17):2050-2.
• Roe DA. Drug and nutrient interactions in the elderly diabetic. Drug Nutr Interact. 1988;5(4):195-203. Review.
• Alcohol use should be limited as it can interfere with diabetes management.
• Facts and Comparisons, Clinisphere 2.0, Wolters Kluwer Company, 2000
• Pronsky, Z Food Medication Interactions, 11th edition, 1999
• Vitamin E may play a beneficial role in protecting against diabetic complications. However, because it can lower blood sugar levels do not supplement large doses of the vitamin without consulting a pharmacist.
• Paolisso G, D'Amore A, Giugliano D, et al. Pharmacologic doses of vitamin E improve insulin action in healthy subjects and non-insulin-dependent diabetic patients. Am J Clin Nutr 57:650-656, 1993
• Ceriello A, Giugliano D, Quatraro A, Donzella C, Dipalo G, Lefebvre PJ. Vitamin E reduction of protein glycosylation in diabetes. New prospect for prevention of diabetic complications? Diabetes Care. 1991 Jan;14(1):68-72.
• Tutuncu NB, Bayraktar M, Varli K. Reversal of defective nerve conduction with vitamin E supplementation in type 2 diabetes: a preliminary study. Diabetes Care. 1998 Nov;21(11):1915-8.
• Potatoes can interfere with blood sugar levels and Amaryl dosage may require adjustment.
• Gannon MC, et al. Diabetes Care 1993;16:874.
• The Review of Natural Products, Facts and Comparisons, Clinisphere 2.0, Wolters Kluwer Company, 2000
• The following herbs may lower blood sugar levels: Alfalfa, Aloe vera, Bilberry, Bitter melon, Burdock, Celery, Cornsilk, Eucalyptus, Fenugreek, Garlic, Ginger, Panax Ginseng, Juniper, Marshmallow, Myrrh, Nettle, Onions, Sage and Tansy.
• Newall CA, Anderson LA, Phillipson JD. Herbal Medicines A Guide for Health-care Professionals. London: The Pharmaceutical Press, 1996.
• Brinker F. Herb contraindications and drug interactions, 2nd ed. Eclectic Medical Publications, 1998.
• Welihinda J, et al. Effect of Momordica charantia on the glucose tolerance in maturity onset diabetes. J Ethnopharmacol 17: 277-282, 1986.
• Licorice is contraindicated in diabetes.
• Newall CA, Anderson LA, Phillipson JD. Herbal Medicines A Guide for Health-care Professionals. London: The Pharmaceutical Press, 1996.
• Brinker, F Herb Contraindications and Drug Interactions, Eclectic Medical Publications, 1998