RNAgent’s Drug Interaction Database indexes and lists prescription drugs and their interactions with herbal supplements. Search by letter or keyword to find a prescription drug and its interactions with herbal and natural ingredients.
Alprazolam
- Alcohol can increase both the sedative and the intoxifying effects of Alprazolam. Use of alcohol should be avoided.
- Pronsky, ZM: Food-Medication Interactions, 11th edition, 1999
- Facts and Comparisons, Clinisphere 2.0, Wolters Kluwer Company, 2000
- Melatonin levels may be diminished with long term use of benzodiazepines like alprazolam. Consult a pharmacist or physician regarding the need for melatonin supplementation and the benefits of using melatonin to withdraw the use of benzodiazepines.
- Kabuto M, Namura I, Saitoh Y. Nocturnal enhancement of plasma melatonin could be suppressed by benzodiazepines in humans. Endocrinol Jpn. 1986 Jun;33(3):405-14.
- McIntyre IM, Norman TR, Burrows GD, Armstrong SM. Alterations to plasma melatonin and cortisol after evening alprazolam administration in humans. Chronobiol Int. 1993 Jun;10(3):205-13.
- Garfinkel D, Zisapel N, Wainstein J, et al. Facilitation of benzodiazepine discontinuation by melatonin: a new clinical approach. Arch Intern Med 159: 2456-2460, 1999.
- Tobacco may increase the rate of elimination of Alprazolam and thereby decrease its effects. Avoid using both together.
- Brinker, F Herb Contraindications and Drug Interactions, Eclectic Medical Publications, 1998
- The following herbs have sedative qualities and could intensify the effects of Alprazolam: calamus, calendula, chamomile, California poppy, catnip, couch grass, elecampane, ginseng Siberian, goldenseal, gotu kola, hops, Jamaican dogwood, kava, lemon balm, sage, St. John's wort, sassafras, scullcap, shepherd's purse, stinging nettle, valerian, withania root, and yerba mansa.
- Newall CA, Anderson LA, Phillipson JD. Herbal Medicines A Guide for Health-care Professionals. London: The Pharmaceutical Press, 1996.
- Almeida JC. Coma from the health food store: Interaction between kava and alprazolam. Ann Intern Med 1996;125:940-41.
- Brinker F. Herb contraindications and drug interactions, 2nd ed. Sandy, OR: Eclectic Medical Publications, 1998
- Speroni E, et al. Sedative effects of crude extract of Passiflora incarnata after oral administration. Phytother Res 10: S92-94, 1996.
- PDR for Herbal Medicine, 2nd edition, Medical Economics Company, 2000
- The Review of Natural Products, Clinisphere 2.0, Wolters Kluwer Company, 2000