Aleve

• Folate and vitamin C supplementation may be helpful with long term use of the medication.
• Baggott JE, Morgan SL, Ha T, et al. Inhibition of folate-dependent enzymes by non-steroidal anti-inflammatory drugs. Biochem J 282: 197-202, 1992.
• Lawrence VA, Loewenstein JE, and Eichner ER. Aspirin and folate binding: in vivo and in vitro studies of serum binding and urinary excretion of endogenous folate. J Lab Clin Med 103: 944-948, 1984.
• Molloy TP and Wilson CW. Protein-binding of ascorbic acid. Interaction with acetylsalicylic acid. Int J Vitam Nutr Res 50: 387-392, 1980.
• Das N and Nebioglu S. Vitamin C-aspirin interactions in laboratory animals. J Clin Pharm Ther 17: 343-346, 1992.
• Vitamin E intake with NSAIDs may increase risk of bleeding.
• Liede KE, Haukka JK, Saxen LM, et al. Increased tendency toward gingival bleeding caused by joint effect of alpha-tocopherol supplementation and acetylsalicylic acid. Ann Med 30: 542-546, 1998.
• Steiner M. Vitamin E, a modifier of platelet function: rationale and use in cardiovascular and cerebrovascular disease. Nutr Rev. 1999 Oct;57(10):306-9.
• Chondroitin sulfate has some anti-platelet properties; consult a pharmacist prior to using NSAID's and chondroitin together due to the increased potential for bleeding.
• Griffith, Winter H MD Vitamins, herbs, minerals and supplements- the complete guide. Revised edition. Fisher books, 1998.
• McKevoy GK, ed. AHFS Drug Information. Bethesda, MD: American Society of Health-System Pharmacists, 2000.
• Take with food to avoid stomach upset.
• Facts and Comparisons, Clinisphere 2.0, Wolters Kluwer Company, 2000
• Pronsky, Z Food Medication Interactions, 11th edition, 1999
• Ulcers induced by NSAIDs may be minimized by Licorice.
• Brinker, F Herb Contraindications and Drug Interactions, Eclectic Medical Publications, 1998
• Rees WDW, Rhodes J, Wright JE, et al. Effect of deglycyrrhizinated liquorice on gastric mucosal damage by aspirin. Scand J Gastroenterol 14: 605-607, 1979.
• Due to their blood-thinning properties, taking angelica, anise, arnica, asafoetida, bogbean, boldo, danshen, fenugreek, feverfew, garlic, ginger, ginkgo, ginseng (Panax), horse chestnut, meadowsweet, prickly ash, passionflower, poplar, quassia, red clover, turmeric, and willow with NSAIDs may increase adverse reactions and side effects.
• Rosenblatt M and Mindel J. Spontaneous hyphema associated with ingestion of Ginkgo biloba extract. N Engl J Med 336(15): 1108, 1997.
• Newall CA, Anderson LA, Phillipson JD. Herbal Medicines A Guide for Health-care Professionals. London: The Pharmaceutical Press, 1996.
• PDR for Herbal Medicines, 2nd edition, Medical Economics Company, 2000
• The Review of Natural Products, Facts and Comparisons, Clinisphere 2.0, Wolters Kluwer Company, 2000
• Avoid feverfew with NSAID's, the herbs' effect may theoretically be reduced.
• Miller LG. Herbal medicinals: selected clinical considerations focusing on known or potential drug-herb interactions. Arch Int Med 1998;158(20):2200-11.
• The Review of Natural Products, Facts and Comparisons, Clinisphere 2.0, Wolters Kluwer Company, 2000